Who Owns SPERO THERAPEUTICS INC (SPRO)? -- Institutional Holders (2026-06-30)

70 institutions reported holding $48.3M of SPERO THERAPEUTICS INC (SPRO) in SEC 13F filings for 2026-06-30. Largest institutional holders: GSK plc ($20.3M), Pfizer Inc ($5.3M), VANGUARD GROUP INC ($5.2M), RENAISSANCE TECHNOLOGIES LLC ($2.1M), Alphabet Inc. ($2.0M). Source: SEC Form 13F.

RankInstitutionValueSharesChange
1GSK plc$20.3M9.2MHold
2Pfizer Inc$5.3M2.4MHold
3VANGUARD GROUP INC$5.2M2.3MAdded
4RENAISSANCE TECHNOLOGIES LLC$2.1M947,904Trimmed
5Alphabet Inc.$2.0M889,979Hold
6SUSQUEHANNA INTERNATIONAL GROUP, LLP$1.8M807,590Added
7BlackRock, Inc.$1.3M594,404Added
8GEODE CAPITAL MANAGEMENT, LLC$1.3M566,329Added
9RAYMOND JAMES FINANCIAL INC$1.2M521,705New
10TWO SIGMA INVESTMENTS, LP$846,019382,814Trimmed
11ARROWSTREET CAPITAL, LIMITED PARTNERSHIP$735,864332,970New
12GSA CAPITAL PARTNERS LLP$632,000285,906Added
13DIMENSIONAL FUND ADVISORS LP$607,616274,820Added
14GOLDMAN SACHS GROUP INC$567,937256,985New
15JANE STREET GROUP, LLC$512,713231,997Added
16STATE STREET CORP$474,600214,751Hold
17UBS Group AG$308,693139,680Added
18SIMPLEX TRADING, LLC$298,376135,012Added
19BRIDGEWAY CAPITAL MANAGEMENT, LLC$253,708114,800Hold
20NORTHERN TRUST CORP$239,286108,274Trimmed
21Point72 Asset Management, L.P.$230,673104,377Added
22Ionic Capital Management LLC$226,963102,698Trimmed
23Federation des caisses Desjardins du Quebec$202,18091,900New
24Shay Capital LLC$159,98472,391Added
25GROUP ONE TRADING LLC$159,49372,169Added

Source: SEC Form 13F filings · as of 2026-06-30